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AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

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Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and necessary to fully understand diseases like obesity, diabetes, asthma & cancer.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. Yes

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. Life-course gut microbiome development

If you did not find your method for obtaining Data Item #1 in the dropdown selection above, please enter it here. Rectal swab or stool sampling per current protocols

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Quarterly

If you did not find your methodology specifications for Data Item #1 above, please enter it here. periodically enough to track natural changes and perturbations from diet, antibiotic use, etc.

If Data Item #2 was not in the dropdown, please enter it here. Antibiotic use history

If Method #2 was not in the dropdown, please enter it here Infancy through early childhood most critical; retrospective use history of mother also important, or document prospectively to follow birth cohorts

Specification #2 Quarterly

If Specification #2 was not in the dropdown, please enter it here: histories taken in allignment with microbiome sampling

Data Item #3 History, obstetric

If Data Item #3 was not in the dropdown, please enter it here Birth mode of both participant & mother (vaginal vs surgical with/without vaginal swabbing) as an influence on microbial colonization

If Method #3 was not in the dropdown, please enter it here Self-report or medical record

Specification #3 Once

Data Item #4 Environmental exposure

If Method #4 was not in the dropdown, please enter it here blood, metabolites, hair, & existing government geospatial health & exposure data

Specification #4 Once per year

If Specification #4 was not in the dropdown, please enter it here Life-course

Data Item #5 Stress

If Data Item #5 was not in the dropdown, please enter it here Self-reported stress & stress physiology

If Method #5 was not in the dropdown, please enter it here self-report stress + blood, metabolites & hair

Specification #5 Quarterly

If you have more than five data items, you may enter them here.

Dietary intake of artificial sweeteners.
Metabolic syndrome measures & other disease-specific metabolic parameters.
Inflammatory markers (various).
Physical activity (Houston Non-Exercise Questionnaire (Jackson, Wier, & Ross, 1995)) - a brief self-report measure that correlates with VO2Max.
Multiple additional measures likely already being assessed can be used to specify myriad pathways for particular diseases.

Notes: The BPSEM can also be applied to elucidating infectious disease pathways, and is currently being applied to zoonosis in One Health.

Reference for biopsychosocial ecological model with general illustration of domains, levels & pathways: Maier, K. J. & al'Absi, M. (2017). Toward a biopsychosocial ecology of the human microbiome, brain-gut axis, and health. Psychosomatic Medicine, 79, 947-957. https://journals.lww.com/psychosomaticmedicine/Fulltext/2017/10000/Toward_a_Biopsychosocial_Ecology_of_the_Human.15.aspx

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