AoU Research Priorities Use Cases

Bridging the gap between obstetric history (preeclampsia) and future women's health and cardiovascular outcomes

2 possible designs:

1) Enroll women diagnosed with preeclampsia (PEC) during current pregnancy and collect data (phenotype & biomarkers), follow up prospectively until cardiovascular events (acute coronary events, strokes, including cardiac surgery)

2) Ambidirectional design: enroll women with a PEC history now having cardiac surgery/cardiopulmonary bypass (CPB); collect biomarkers & clinical outcomes (phenotype after CPB) comparing CPB outcomes among women who had PEC vs those who did not.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. Obstetric history

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Electronic Health Records (EHR)

If you did not find your method for obtaining Data Item #1 in the dropdown selection above, please enter it here. EHR and or patient history

If Data Item #2 was not in the dropdown, please enter it here. cardiac outcomes

Method #2

Specification #2 At specified times anchored to the clinical event

Data Item #3

If Data Item #3 was not in the dropdown, please enter it here Cardiopulmonary bypass outcome

Method #3 Electronic Health Records (EHR)

If Method #3 was not in the dropdown, please enter it here ICU admission, treatment

Specification #3 Continuous monitoring

Data Item #4 Genome

Method #4 Whole Exomic Sequencing (WES)

Specification #4 Once

Keywords

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Idea No. 39