AoU Research Priorities Use Cases

Bridging the gap between obstetric history (preeclampsia) and future women's health and cardiovascular outcomes

2 possible designs:

1) Enroll women diagnosed with preeclampsia (PEC) during current pregnancy and collect data (phenotype & biomarkers), follow up prospectively until cardiovascular events (acute coronary events, strokes, including cardiac surgery)

2) Ambidirectional design: enroll women with a PEC history now having cardiac surgery/cardiopulmonary bypass (CPB); collect biomarkers & clinical outcomes (phenotype after CPB) comparing CPB outcomes among women who had PEC vs those who did not.

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Idea No. 39