AoU Research Priorities Use Cases

Can measures of speech and language be pre-clinical predictors of neurological disease?

Complex brain networks are responsible for translating thoughts and ideas into sequences of movements that produce the sounds of speech. Any disturbance in these networks can lead to changes in how we speak and what we say. Evidence shows that subtle changes in speech are early harbingers of neurological disease. We propose to use the AoU platform to validate this hypothesis on a large scale and to develop AI tools for early detection based on speech analytics.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. Behavioral measures

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. Speech samples

If you did not find your method for obtaining Data Item #1 in the dropdown selection above, please enter it here. Smartphone application that elicits speech samples from participants.

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Weekly

Data Item #2 Clinical outcomes

If Data Item #2 was not in the dropdown, please enter it here. Disease Diagnosis

Method #2 Electronic Health Records (EHR)

Specification #2 At specified times anchored to the clinical event

Data Item #3 Behavioral measures

If Data Item #3 was not in the dropdown, please enter it here cognitive testing

If Method #3 was not in the dropdown, please enter it here Mobile app

Specification #3 Once per year

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Idea No. 622