Goals: To determine genetics of response to biologic drugs in RA
Methods: Define RA with EHR algorithm, use mHealth app to record RA symptoms (RADAI), current/new meds + adherence
Outcome: daily RA disease activity after drug start
Data: EHR meds, ESR, CRP; PPI confounders, demographics, smoking, exercise.
Limitations of prior studies: small samples, no adherence or confounder info, sparse outcome data
Expected outcomes: PGx of drug response in RA, model for PGx in other chronic diseases.