Can we use an mHealth app to track rheumatoid arthritis symptoms and conduct pharmacogenetics analyses for biologic drugs?

Goals: To determine genetics of response to biologic drugs in RA

Methods: Define RA with EHR algorithm, use mHealth app to record RA symptoms (RADAI), current/new meds + adherence

Outcome: daily RA disease activity after drug start

Data: EHR meds, ESR, CRP; PPI confounders, demographics, smoking, exercise.

Limitations of prior studies: small samples, no adherence or confounder info, sparse outcome data

Expected outcomes: PGx of drug response in RA, model for PGx in other chronic diseases.