AoU Research Priorities Use Cases

Conduct research to determine if blood can help identify the presence of the HPV-16 virus.

Goal: save millions of lives. A person dies from oral cancer every hour of every day.

Methodology:

- Include people diagnosed with oral and oropharyngeal cancer caused by the HPV-16 virus

- Collect and analyze blood every 3 months within the first 2 years of diagnosis. Between 2 and 5 years do it every 4 months

Outcome: increase the survival rate. The death rate is about 43% at five years from diagnosis. When found at early stages of development oral cancers have an 80 to 90% survival rate.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. Genome

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Whole Genome Sequencing (WGS)

If you did not find your methodology specifications for Data Item #1 above, please enter it here. Collect and analyze blood samples every 3 months within 2 years of diagnosis. Collect and analyze blood samples every 4 months between 2 and 5 years of diagnosis.

Data Item #2 Genome

If Method #2 was not in the dropdown, please enter it here TCGA

If Specification #2 was not in the dropdown, please enter it here: Proposing something similar to what is described in NIH TCGA in Action Article titled, “CASE STUDY: A Researcher Mined TCGA Data to Study Her Own Ovarian Cancer , Amy E. Blum, M.A, December 6, 2016.

Data Item #3 Stress

Method #3 Blood test

If Specification #3 was not in the dropdown, please enter it here Cortisol every 3 months within 2 years of diagnosis; every 4 months from 2-5 years of diagnosis

Data Item #4 Stress

Method #4 Activity monitor

If Specification #4 was not in the dropdown, please enter it here Wearable for continuous monitoring of heart information

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Idea No. 316