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Contribution of genetic, environmental, and dietary factors to peripheral atherosclerosis

Peripheral artery disease (PAD) affects about 13% of the population over 50 years and it is an important cause of morbidity and mortality. The ankle brachial index (ABI) is an inexpensive and non-invasive test used to screen for PAD, and an abnormal value is associated with increased cardiovascular events. Adding the collection of serial ABIs to the All of US database will allow for numerous future studies aimed at defining the role of genetic and environmental factors in the development of PAD.

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Idea No. 829