AoU Research Priorities Use Cases

Contribution of genetic, environmental, and dietary factors to peripheral atherosclerosis

Peripheral artery disease (PAD) affects about 13% of the population over 50 years and it is an important cause of morbidity and mortality. The ankle brachial index (ABI) is an inexpensive and non-invasive test used to screen for PAD, and an abnormal value is associated with increased cardiovascular events. Adding the collection of serial ABIs to the All of US database will allow for numerous future studies aimed at defining the role of genetic and environmental factors in the development of PAD.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. Yes

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. ankle brachial index

If you did not find your method for obtaining Data Item #1 in the dropdown selection above, please enter it here. Doppler study

Data Item #2 Genome

Method #2 Whole Genome Genotyping (WGG)

Data Item #3 Diet

Method #3 Survey

Data Item #4 History, lifestyle

Method #4 Survey

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Idea No. 829