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Development of Clinically Relevant Cellular-based microbiosensors and Stable, Robust Genetic Circuits

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As cell-based strategies constitute a novel paradigm in microbiome therapeutics, an emerging U24 and U41 framework focused on using natural and recombinant probiotics, their designed microbial consortia and their validated selective antimicrobials. Recent efforts seek to augment the natural benefits of probiotics through recombinant expression of therapeutic biomolecules, which could overcome issues such as bioavailability and drug inactivation associated with oral administration.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

If you did not find your method for obtaining Data Item #1 in the dropdown selection above, please enter it here. genetic circuits integrated with micro-biosensors

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Idea No. 854