Integrate multi-omic approaches (metabolomic, proteomic, inflammasome, microbiome analyses) with dietary assessment and clinical data in a nested cohort study. Dietary and/or microbial metabolites may modulate body weight and may influence other comorbidities. A comprehensive analysis of inflammatory and metabolic biomarkers of oxidative stress, nutritional assessment, short chain fatty acids and other microbial metabolites may provide predictive markers of weight gain or obesity.
Idea No. 609