AoU Research Priorities Use Cases

Do antidepressants interact with cognitive decline to increase the risk of falls that result in injury

A retrospective analysis of longitudinal health data from the EHR and self reports of patients who are chronic users of antidepressants. Both antidepressants and cognitive decline are associated with falls and repeated falls, a major source of morbidity/mortality. Antidepressants are poorly studied in patients experiencing cognitive decline. The study would test for a synergistic interaction between the drug class and disease, possibly suggesting a clinical management strategy.



10 votes
Idea No. 469