AoU Research Priorities Use Cases

Do blood biomarkers predict mood transitions for peripartum mood disorder (PPMD)?

Mood disorder in pregnant and postpartum women is common, often severe, but frequently undiagnosed and untreated, and largely understudied. I propose to augment the AllofUs protocol for research into PPMD by adding collection of biospecimens for OMIC measurements at fixed times relative to pregnancy, and also when triggered by alerts of critical clinical mood state shifts as informed by wearable technology or computerized adaptive technology (CAT-MH by Robert Gibbons) self-report monitoring.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. Yes

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. Depression

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Smartphone Ecological Momentary Assessment

If you did not find your method for obtaining Data Item #1 in the dropdown selection above, please enter it here. Augmented by EHRs, surveys, and physical monitoring of signs of mood disorder (depression, etc.)

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. At specified times anchored to the clinical event

If you did not find your methodology specifications for Data Item #1 above, please enter it here. Augmented by one or more baseline measurements at fixed times during pregnancy and after delivery.

Data Item #2 Genome

Method #2 Whole Genome Genotyping (WGG)

If Method #2 was not in the dropdown, please enter it here WES or WGS if available

Specification #2 Once

If Data Item #3 was not in the dropdown, please enter it here One or more OMIC measurements such as microbiome, metabolome, transcriptome, and proteome.

If Method #3 was not in the dropdown, please enter it here Blood and urine samples

Specification #3 At specified times anchored to the clinical event

If Specification #3 was not in the dropdown, please enter it here One or more baseline measurements at fixed times during pregnancy and after delivery.

Method #4 Blood test

If Method #4 was not in the dropdown, please enter it here One or more pregnancy related hormones as available

Data Item #5 Sociodemographics

If Data Item #5 was not in the dropdown, please enter it here Other various items in the drop-down list as relevant to PPMD risk factors

Method #5 Electronic Health Records (EHR)

If Method #5 was not in the dropdown, please enter it here Augmented by mental health, demographics, and other surveys.

Specification #5 Once

If Specification #5 was not in the dropdown, please enter it here Once or more as needed for longitudinal phenotyping, including future pregnancies during the participants' AllofUs tenure.

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Idea No. 230