AoU Research Priorities Use Cases

Do genomic data provide clinically useful information beyond the data gathered during standard clinical care?

1. A cohort of people with WGS and pharmacogenomic data from blood sample. Randomize half of to get data in easily available tissues: DNA sequence (for somatic variants and mosaicism), RNA expression, and epigenomic data. Compare health outcomes between both groups..

 

2. Assay all data types in a group and consider when genomics made a difference in their healthcare outcomes. For this approach we would need methods to estimate their health had the genomic data not been used.

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Idea No. 812