1. A cohort of people with WGS and pharmacogenomic data from blood sample. Randomize half of to get data in easily available tissues: DNA sequence (for somatic variants and mosaicism), RNA expression, and epigenomic data. Compare health outcomes between both groups..
2. Assay all data types in a group and consider when genomics made a difference in their healthcare outcomes. For this approach we would need methods to estimate their health had the genomic data not been used.