AoU Research Priorities Use Cases

Do systemic therapies used for cure or control of diseases like cancer, HIV, or diabetes alter aging phenotypes?

Clinical evidence suggests that cancer survivors, people living with HIV/AIDS, and diabetics may age prematurely from treatment toxicity. The All of Us study could be used to study these observatons over time by comparing aging trajectories and risk factors for individuals with and without systemic therapy use and investigate the mechanisms that cause alterations in the rate or way individuals age.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. Yes

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. Cancer incidence

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Linkage with virtual tumor registry to ensure complete case ascertainment

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Include child, teenager, early adult, adult, elderly

If Data Item #2 was not in the dropdown, please enter it here. functional outcomes

If Method #2 was not in the dropdown, please enter it here repeated frailty and geriatric-like assessments

If Specification #2 was not in the dropdown, please enter it here: Periodically

If Data Item #3 was not in the dropdown, please enter it here treatment exposure

Method #3 Electronic Health Records (EHR)

Specification #3 At specified times anchored to the clinical event

Data Item #4 Clinical outcomes

Method #4 Electronic Health Records (EHR)

Specification #4 Quarterly

If Data Item #5 was not in the dropdown, please enter it here Aging biomarkers

If Method #5 was not in the dropdown, please enter it here assays of a variety of bomarkers associated with hallmarks of aging

If Specification #5 was not in the dropdown, please enter it here Periodically

If you have more than five data items, you may enter them here.

Comorbidities; history, lifestyle; history, current medication use; epigenetic markers; behavioral measures, SES indicators; sociodemgraphics, residential history; adverse childhood experiences; cognitive functioning, environmental exposures, depression, fatigue, CRP, inflammatory cytokines, biological age (Horvath and Belsky methods); metabolic risk profile; history, mental health; stress exposure; VO2max; sedentary behavior; physical activity; diet history; social isolation; gene expression

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Idea No. 802