AoU Research Priorities Use Cases

Does collecting side-effect data directly from patients improve compliance, personalized drug choice and efficacy?

After a drug has been approved, big ADRs are reported to MEDRA, but smaller side effects are not usually reported. While some may be known and in the drug label, novel side effects may occur in populations not included in the original trials. Small effects may lead to discontinuation or poor compliance.. Collecting better data about side effects and combining with genomic data could give improved pharmacogenomic prediction of side effects and allow for better selection of drugs for a patient.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. Side effects

If you did not find your method for obtaining Data Item #1 in the dropdown selection above, please enter it here. App that allows patients to report which drugs they are taking and the side effects incurred

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Quarterly

Data Item #2 Genome

Method #2 Whole Genome Sequencing (WGS)

Specification #2 Once

Data Item #3 Current medication use

Method #3 Prescription records

Specification #3 Quarterly

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Idea No. 363