AoU Research Priorities Use Cases

Exposures to environmental chemicals during pregnancy and effects on epigenetic biomarkers of metabolic syndrome and obesity

Obesity and breast cancer are leading cause of morbidity and mortality. Evidence strongly suggests that certain periods of life, including those during fetal development and pregnancy, influence risk of breast cancer later in life. Environmental chemicals may increase breast cancer risk-especially during pregnancy-by mimicking estrogen and other hormones. Epigenomic signatures present in the placenta uniquely capture the effects of endogenous and environmental exposures for both mother and baby.



9 votes
Idea No. 527