AoU Research Priorities Use Cases

Exposures to environmental chemicals during pregnancy and effects on epigenetic biomarkers of metabolic syndrome and obesity

Obesity and breast cancer are leading cause of morbidity and mortality. Evidence strongly suggests that certain periods of life, including those during fetal development and pregnancy, influence risk of breast cancer later in life. Environmental chemicals may increase breast cancer risk-especially during pregnancy-by mimicking estrogen and other hormones. Epigenomic signatures present in the placenta uniquely capture the effects of endogenous and environmental exposures for both mother and baby.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. Yes

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. Pathologically confirmed diagnosis of breast cancer, including clinico-pathology characteristics of the tumor

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Electronic Health Records (EHR)

If you did not find your methodology specifications for Data Item #1 above, please enter it here. Linkage with virtual tumor registry to ensure complete case ascertainment; quarterly

If Data Item #2 was not in the dropdown, please enter it here. placenta

If Method #2 was not in the dropdown, please enter it here Paraffin-embedded tissue blocks using placenta collected after the baby’s birth

If Specification #2 was not in the dropdown, please enter it here: Epigenomic signatures based on tissue samples

If Data Item #3 was not in the dropdown, please enter it here Age, reproductive and hormone use history, BMI, smoking, alcohol/drugs, physical activity, genetics, other diseases, family history of cancer, and other risk factors for breast cancer

Method #3 Survey

If Specification #3 was not in the dropdown, please enter it here Baseline and follow-up surveys, and EHR; every 3 years

Data Item #4 Mammography breast density (Bi-RADS)

If Method #4 was not in the dropdown, please enter it here Retrieval of digital images of mammograms would be desirable to obtain additional features

Specification #4 Every three years

Data Item #5 Environmental exposure

If Method #5 was not in the dropdown, please enter it here urine and blood

If Specification #5 was not in the dropdown, please enter it here chemicals and/or heavy metals

If you have more than five data items, you may enter them here.

Diagnostic FFPE blocks of breast tumors to describe molecular subtype

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Idea No. 527