How can we better understand fatigue, depression, and cognitive dysfunction in Sjögren's and other autoimmune diseases?

Autoimmune diseases, such as Sjögren's, manifest themselves in a wide variety of ways in patients. However, a common thread in many of these diseases is fatigue, depression, and cognitive dysfuction, or "brain fog." These physical and mental manifestations can have serious, debilitating, consequences for those who suffer with them. A better understanding of the pathways of these manifestations will allow for a more informed approach to care and the ability to better address the symptoms.