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How do inflammation and subclinical autoimmunity impact adverse reproductive health?

Preterm delivery is a serious problem. SLE and RA patients have increased pregnancy morbidity before diagnosis and their healthy sisters have increased rates of pregnancy complications. Therefore, pre-clinical autoimmunity or inflammation may affect pregnancy outcomes. Reproductive and family history, and rheumatic disease symptoms, would be collected and correlated with hsCRP levels and autoantibody production in a nested study to help reduce pregnancy risks and neonatal morbidity.

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Idea No. 814