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Possibility of Using Probiotics as Programmable Delivery Vehicles for Diagnostic agents in Cancer Prevention and Biotherapeutics

Motivated by the need for accessible, highly sensitive, and selective tools for detection of small metastases that are beyond the reach of existing diagnostic tools programmable live cell probiotic micro-biosensors with CRISPR expression cassettes may also be an appropriate vehicle for developing an oral, broad-spectrum diagnostic for cancers that frequently result in liver metastases. Probiotic microbial diagnostics that can sensitively, specifically, and safely detect tumors is the hope.

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Idea No. 856