AoU Research Priorities Use Cases

The AoU Exposome Study: Untargeted Discovery of environment-disease associations

The exposome has been defined as the totality of environmental exposures throughout the life-course. Regardless of the definition it is as a tool for the untargeted hypothesis free discovery of associations between environmental exposures and disease outcomes. This is best applied to high prevalence phenotypes that are likely to occur in the cohort such as the conversion of metabolic syndrome to overt diabetes where it can be nested as a case-control study.

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Idea No. 662