AoU Research Priorities Use Cases

The effects of alcohol (and other drug) consumption on major somatic diseases and psychiatric disorders and their treatments.

Alcohol affects nearly all major diseases. Failing to capture lifetime alcohol exposure will adversely affect the goals of All of Us.

There are better questions about consumption, that should be asked of previous year, typical year and heaviest year.

Questions should be asked about problems due to alcohol, and those should be focused on lifetime.

Additional questions about other drugs should also be included.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. Lifetime consumption, including periods of heaviest use, of alcohol and drugs of abuse.

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Survey

If you did not find your method for obtaining Data Item #1 in the dropdown selection above, please enter it here. suggestions about survey questions noted above. Food questionnaire and limitation to previous year are NOT adequate.

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Every two years

If Data Item #2 was not in the dropdown, please enter it here. Problems related to alcohol (and drug) use

Method #2 Survey

Specification #2 Every two years

If Data Item #3 was not in the dropdown, please enter it here Real time alcohol monitoring by transdermal sensor

Method #3 Mobile monitor

If Method #3 was not in the dropdown, please enter it here NIAAA has identified such a transdermal monitor

Specification #3 Once per year

If you have more than five data items, you may enter them here.

There is a glaring inadequacy in the ppi_survey_lifestyle. Problems due to alcohol and drugs are notoriously under-reported in electronic health records, which greatly diminishes our ability to understand the effects of alcohol and drugs on health and longevity, the key questions being addressed by the All of Us program. Alcohol affects nearly all major diseases, and lifetime exposure is more relevant than past year because many problems take years to develop. Yet there is minimal coverage, based upon 3 consumptioin questions from the AUDIT-C focused only on the previous year. Failing to capture lifetime alcohol exposure is a major shortcoming, and will adversely affect the overall goals of All of Us because excessive alcohol consumption for any duration during the lifetime can have major effects on nearly all major diseases. Also, there are important issues about the potentially beneficial effects of moderate alcohol consumption on cardiovascular events and lifespan.

There are far better questions to ask about alcohol and other drugs, including going beyond mere consumption to ask about problems related to consumption: https://www.niaaa.nih.gov/research/guidelines-and-resources/recommended-alcohol-questions
Their 6 question set is a reasonable start for consumption, but should also be asked about the period of heaviest consumption during one’s lifetime as well as typical consumption across lifetime and years of use. The latter, lifetime measures are more relevant to chronic diseases.
More questions should be asked about problems due to alcohol, and those should be focused on lifetime or period of heaviest use.

For problems, the remainder of AUDIT-C is a reasonable start, but it would be much better to convene an expert panel to develop the best set of questions about problems related to alcohol and drugs. NIAAA and NIDA could jointly convene such a panel, even on short notice.

Additional questions about other drugs should also be a part, designed to appear if the participant acknowledges use of any of the other drugs.

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Idea No. 117