AoU Research Priorities Use Cases

Understanding the pathogenesis of type 1 diabetes

Use a case-cohort study, identifying cases through the EHS system and confirming through a variety of clinical laboratory tests. We know little about the genetic basis of T1D in African-ancestry (non-white) populations or T1D with onset in adulthood, These data would also provide insights on the rates and types of complications that may differ between adult-onset T1D and childhood-onset T1D.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. Diseased, Missing, Filled Surface Score (DMFS)

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Electronic Health Records (EHR)

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. At specified times anchored to the clinical event

Data Item #2 Genome

Method #2 Whole Genome Sequencing (WGS)

Specification #2 Once

Data Item #3 HLA genotypes

Method #3 HLA test

Specification #3 Once

Data Item #4 Hemoglobin A1C (HbA1C)

Method #4 Blood test

Specification #4 Once per year

Data Item #5 Clinical outcomes

Method #5 Electronic Health Records (EHR)

Specification #5 Once per year


8 votes
Idea No. 480