AoU Research Priorities Use Cases

Using human microbiome data to improve pathogenesis and treatment of infectious diseases

Precision microbiome engineering could be applied to vaccine delivery, immunology, drug-resistant infections, and post-surgical infections.

 

Specific research questions re pathogenesis and treatment:

 

- What aspects of the indigenous microbiota mediate colonization resistance against C. difficile, as well as other multi-drug resistant organisms such as carbapenamase-producing gram negative bacteria and vancomycin resistant enterococci?

- Determine optimal C. diff treatment to prevent relapse

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Idea No. 492