AoU Research Priorities Use Cases

What are the biological and behavioral factors that predict mesh complications after sling for stress urinary incontinence?

Stress urinary incontinence (SUI) is prevalent among women, yet the standard of care treatment – midurethral mesh sling – can lead in devastating mesh complications (dyspareunia that precludes sex, chronic pelvic pain, infection). Using national data, we will identify biological (eg, genomics, vaginal & urinary microbiome, race, comorbidities, metabolic syndrome) and behavioral (eg, smoking, physical activity) factors that predict mesh complications after midurethral sling treatments for SUI.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. Yes

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. History, health

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. History of SUI, midurethral sling surgery, midurethral sling complications, surgery for sling complications

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Electronic Health Records (EHR)

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Baseline and 1 year following surgery

Data Item #2 Urinary 'biome': 16S bacterial DNA, virome, metabalome

Method #2 Urine

If Method #2 was not in the dropdown, please enter it here Consider vaginal swab for vaginal microbiome also

Specification #2 At specified times anchored to the clinical event

Data Item #3 Genome

Method #3 Blood test

Specification #3 At specified times anchored to the clinical event

Data Item #4 Physical activity level

Method #4 Mobile monitor

Specification #4 Mobile monitors would be used continuously for one week duration at 1 month, 6 months, and 1 year after injury

If Specification #4 was not in the dropdown, please enter it here Mobile monitors would be used continuously for one week at 1 month, 6 months and 1 year after SURGERY

Data Item #5 Metabolic risk profile

Method #5 Survey

If Method #5 was not in the dropdown, please enter it here Plus EHR and blood work information

Specification #5 Once

If Specification #5 was not in the dropdown, please enter it here Metabolic syndrome: blood pressure, waist circumference, BMI, medication, medical history, biochemical assays, HDL, LDL, glucose, triglyceride, HgA1c

If you have more than five data items, you may enter them here.

Others – demographics (eg, ethnicity, age, sex), socioeconomic background (eg, insurance, access to health care)

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Idea No. 725