AoU Research Priorities Use Cases

What are the long-term effects and risks of opioid use disorder during pregnancy on maternal and child health?

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. Depression

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Survey

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Once per year

Data Item #2 Opioid screen

Method #2 Urine

If Specification #2 was not in the dropdown, please enter it here: Monthly screening of opioid using pregnant women and infants born from opioid using mothers

If Data Item #3 was not in the dropdown, please enter it here Treatments and follow-up outcome history

Method #3 Electronic Health Records (EHR)

Specification #3 Once per year

If Data Item #4 was not in the dropdown, please enter it here Physiologic markers related to effects of opioid withdrawal in children

If Method #4 was not in the dropdown, please enter it here Blood and Urine tests

If Specification #4 was not in the dropdown, please enter it here Annual collections from birth through 5 years of age

If Data Item #5 was not in the dropdown, please enter it here Physiologic markers related to effects of opioid use and withdrawal in pregnant women with opioid use disorder

If Method #5 was not in the dropdown, please enter it here Blood and Urine tests

If Specification #5 was not in the dropdown, please enter it here Baseline, first trimester, monthly through delivery, and one year postpartum

If you have more than five data items, you may enter them here.

-Geocoding Information
-Family caregiver and family environment information (e.g., sociodemographics, physical, social, and emotional) post-discharge of the infant, with frequent monitoring as the infant may be moved periodically depending on the mother’s substance use status, foster care arrangements and kinship arrangements.
-Hospitalizations history
-Diagnoses and medications related to opioid use in the mother
-Certificates of confidentiality consideration for EHR because maternal opioid use data may have legal implications for the family
-Early childhood and adolescent school performance records
-Adolescent risk-taking behaviors

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Idea No. 93