AoU Research Priorities Use Cases

What are the molecular factors of heightened sensitivity to air pollution?

Defining heightened sensitivity as an increased hazard ratio for an association between air pollution and a health outcome, identify subsets of the population based on molecular factors, e.g. genetic variants, hypermethylated regions, which are at increases risk of adverse cardiovascular or pulmonary events during high air pollution days.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. Environmental exposure

If you did not find your method for obtaining Data Item #1 in the dropdown selection above, please enter it here. residential address history

Data Item #2 Genome

If Method #2 was not in the dropdown, please enter it here genotyping and DNA methylation arrays

Data Item #3 History, health

Method #3 ICD data

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Idea No. 381