AoU Research Priorities Use Cases

What are the multi-level, environmental exposure endotype pathways of autoimmune inflammation and disease? Reactive airway?

Focusing recruitment on communities with a disproportionate burden of environmental exposures, develop and test a multi-level model to ascertain the burden of autoimmune inflammation, autoimmune disease, and reactive airway attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden, and 5) inflammatory biomarker response levels over time. Ascertain how genetic variation mediates these relationships.



7 votes
Idea No. 606