This would focus on incidence of health problems in the entire cohort to ask if loss of mobility or neurological impairment are separate risk factors. Demographic and pre-enrollment ICD codes will be obtained with the All of Us Core dataset. Volunteers will be followed for 5 years with annual PPI, physical exams, and blood draws. ICD codes will be obtained at any clinical encounters. Principle component analysis will be used to define the primary risk factors associated with comorbidities.