AoU Research Priorities Use Cases

What are the risk factors for comorbid health outcomes in persons with immobility caused by neurological injury or disease?

This would focus on incidence of health problems in the entire cohort to ask if loss of mobility or neurological impairment are separate risk factors. Demographic and pre-enrollment ICD codes will be obtained with the All of Us Core dataset. Volunteers will be followed for 5 years with annual PPI, physical exams, and blood draws. ICD codes will be obtained at any clinical encounters. Principle component analysis will be used to define the primary risk factors associated with comorbidities.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. Yes

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. ICD codes

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Physical exam

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Once per year

Data Item #2 Clinical outcomes

Method #2 Clinical diagnostic tests

If Specification #2 was not in the dropdown, please enter it here: Annual and at any subsequent unscheduled clinical encounter

Data Item #3 Metabolic risk profile

Method #3 Blood test

Specification #3 Once per year

Data Item #4 Lipid panel

Method #4 Blood test

Specification #4 Once per year

Data Item #5 Quality Of Life

Method #5 Survey

Specification #5 Once per year

If you have more than five data items, you may enter them here.

Demographic information, genomics, neurological exam if indicated by clinical diagnosis

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Idea No. 59