AoU Research Priorities Use Cases

What are the unique factors associated with early onset obesity in different ethnic and racial groups?

This study will focus on women who are pregnant when they enroll, or become pregnant during the study, in order to follow their infants from birth to 8 years of age to determine trajectories of growth over time and identify genomic and epigenomic factors related to development of obesity. Critical to obtaining this information will be the review of Electronic Health Records of providers who have the correct measuring tools and personnel to properly measure linear growth in children.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. Professionally measured length/height and weight

If you did not find your method for obtaining Data Item #1 in the dropdown selection above, please enter it here. Stadiometer height and weight measurements according to protocol

If you did not find your methodology specifications for Data Item #1 above, please enter it here. Measurements taken at birth and during well child vaccination visits (2 mo., 3-4 mo., 5-6 mo., 12 mo., 18 mo., 24 mo.) and then annually until age 8

If Data Item #2 was not in the dropdown, please enter it here. Microbiome analysis

If Method #2 was not in the dropdown, please enter it here Fecal biospecimen and microbial genome sequencing

If Specification #2 was not in the dropdown, please enter it here: Annually for 5 years for infants and children

If Data Item #3 was not in the dropdown, please enter it here Oral Glucose Tolerance Test and Adipokines

If Method #3 was not in the dropdown, please enter it here Oral Glucose Tolerance Test from Venous blood specimen

If Specification #3 was not in the dropdown, please enter it here OGTT once during pregnancy; Adipokines twice during pregnancy and annually in infant/child x 5y

If Data Item #4 was not in the dropdown, please enter it here Infant/child feeding practices and child appetitive traits

Method #4 Survey

If Specification #4 was not in the dropdown, please enter it here Annually until age 8, completed by parents

Data Item #5 Genome

Method #5 Whole Exomic Sequencing (WES)

If Specification #5 was not in the dropdown, please enter it here In mother, father, and infant/child

If you have more than five data items, you may enter them here.

-Electronic Health Record provided information: Mother: Pre-pregnancy BMI, gestational weight gain, pregnancy complications and obstetric history; Child: Anthropometry (heights and weights); Feeding.
-Automated Self-Administered 24 Hour Assessment (ASA – 24): Dietary Recall – pregnant mother, mother on behalf of infants and young children, and children (3 samples: two weekday and one weekend).
-Waist circumference; body composition measures (DEXA scan or PEA POD) if feasible in a subset.
-Geocoding information

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Idea No. 82