AoU Research Priorities Use Cases

What characteristics define women with Urinary Incontinence who respond to midurethral sling surgery, versus those who don’t?

Midurethral sling surgery (MuSS) outcomes are inconsistent. We lack knowledge of outcome moderators. This study will identify a prospective subcohort of women aged 18+ with incident successful and unsuccessful MuSS. Hypothesized moderators of MuSS outcome spanning the social ecological model (e.g., urinary microbiome, comorbidities, BMI, physical activity, race, occupation, income) will be compared across those with successful & unsuccessful MuSS outcome to identify determinants of MuSS success.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. Yes

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. midurethral sling surgery

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Electronic Health Records (EHR)

If you did not find your methodology specifications for Data Item #1 above, please enter it here. procedure codes

If Data Item #2 was not in the dropdown, please enter it here. perceived outcomes - surgeon

Method #2 Electronic Health Records (EHR)

If Specification #2 was not in the dropdown, please enter it here: natural language processing of notes

If Data Item #3 was not in the dropdown, please enter it here perceived outcome - patient

Method #3 Survey

If Specification #3 was not in the dropdown, please enter it here validated questionnaire - e.g., Patient Global Impression of Change Scale (PGIC)

If Data Item #4 was not in the dropdown, please enter it here Physical activity level

If Method #4 was not in the dropdown, please enter it here wearable device

If Specification #4 was not in the dropdown, please enter it here wearable data needed prior to MuSS subcohort selection; required for full All Of Us cohort or random subsample

If Data Item #5 was not in the dropdown, please enter it here Occupation

Method #5 Survey

If Specification #5 was not in the dropdown, please enter it here covering bathroom autonomy, lifting requirements, physical activity requirements, availability of sick leave, occupational class

If you have more than five data items, you may enter them here.

health literacy (validated questionnaire), urinary microbiome (urinalysis – longitudinal, within 3 months of surgery), follow-up UI treatment procedures (EHR – procedure codes), race (survey), ethnicity (survey), income (survey), education (survey), anthropomorphic measures (EHR), BMI (EHR), diabetes (EHR), hypertension (EHR), cardiovascular disease (EHR), depression (EHR), anxiety (EHR), arthritis (EHR), constipation (survey), sexual orientation (survey), gender identity (survey), self-efficacy (validated questionnaire), executive functioning (validated questionnaire), marital status (survey), family size (survey), social support (validated questionnaire), estrogen levels (blood sample), menopausal status (survey), medications (EHR), hormone replacement therapy (EHR), functional status (survey), age (EHR), lower urinary tract symptoms (survey)

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Idea No. 26