AoU Research Priorities Use Cases

What characteristics distinguish a healthy maternal pregnancy-microbiome from one that experienced microbial perturbations?

This study will focus on a subsample of all pregnant women and follow them throughout pregnancy to obtain serial assessments and measurements, including laboratory microbiologic evaluation testing of oral, skin and vaginal specimens. Follow-up would end at delivery of the infant; serial pregnancies would be eligible to re-enroll. Assessments and measures would be used along with health outcomes to determine associations and develop predictive models.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. History, obstetric

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Electronic Health Records (EHR)

If you did not find your methodology specifications for Data Item #1 above, please enter it here. Once per month during pregnancy

Data Item #2 History, medication

Method #2 Electronic Health Records (EHR)

If Specification #2 was not in the dropdown, please enter it here: Once per month during pregnancy

If Data Item #3 was not in the dropdown, please enter it here Microbiologic evaluation of oral, skin, and vaginal specimens

If Method #3 was not in the dropdown, please enter it here Physical Exam; oral, skin and vaginal specimen collection, microbiologic genome sequencing

If Specification #3 was not in the dropdown, please enter it here Once per month during pregnancy

Data Item #4 Genome

Method #4 Whole Genome Sequencing (WGS)

If Specification #4 was not in the dropdown, please enter it here Once per month during pregnancy

If Data Item #5 was not in the dropdown, please enter it here Immune and inflammatory biomarkers

Method #5 Blood test

If Specification #5 was not in the dropdown, please enter it here Once per month during pregnancy

If you have more than five data items, you may enter them here.

-Participant provided information spanning the following fields: sociodemographic, environmental context, lifestyle survey, and diet survey
-Pregnancy outcome and medical conditions related to pregnancy
-Mode of delivery history
-Breastfeeding history

Voting

43 votes
Ideate
Idea No. 85