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What genes are associated with temporomandibular joint dysfunction (TMD) and its co-morbid pain conditions?

Temporomandibular joint disorder (TMD), is a group of conditions that cause pain and dysfunction in the jaw joint and muscles that control jaw movement. The 2014 US National Health Interview Survey reported 4.6% of adults reported pain in the face or jaw in the previous 3 months. TMD often overlaps with other pain disorders, including headache, low back pain, and chronic widespread pain. Identification of genes and gene products could allow development of new treatments for chronic pain.

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