AoU Research Priorities Use Cases

What genetic and environmental risk factors contribute to the development of pelvic organ prolapse (POP) as females age?

This study will focus on the entire cohort (menarche through lifespan) to collect data on general health and wellbeing as well as detailed pregnancy & delivery histories. Activity level will be monitored, specifying any straining associated with either physical activity or occupation. Genetic/epigenetic factors, such as family history of POP or connective tissue disorders will be obtained, as will data on other currently suspected risk factors (e.g., smoking, other environmental exposures).

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. POPQ exam

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Physical exam

If you did not find your methodology specifications for Data Item #1 above, please enter it here. Once per year (or at least once every 3 years)

If Data Item #2 was not in the dropdown, please enter it here. POP symptoms

Method #2 Survey

Specification #2 Once per year

Data Item #3 Genome

Method #3 Whole Genome Sequencing (WGS)

Specification #3 Once

Data Item #4 Environmental exposure

Method #4 Survey

Specification #4 Once per year

Data Item #5 Physical activity level

Method #5 Mobile monitor

Specification #5 Quarterly

If you have more than five data items, you may enter them here.

-Participant Provided Information: Age; gender; social history; ethnicity; family history; occupation; income; medication history; history of constipation; gravidity and parity including delivery method history.
-Electronic Health Record provided information: Menstrual history; social history; alcohol/drug use and smoking history; history of constipation; gravidity and parity including delivery method history; any excess straining that may have been due to physical activity (e.g. heavy lifting); medical (e.g. constipation, chronic cough conditions) and surgical history (e.g. any pelvic floor surgery); and mental health history.
-Physical Examination: BMI, height, weight, POP-Quantification
-Geocoding information

Keywords

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Idea No. 87