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What genetic factors are associated with aggressive periodontitis?

Aggressive periodontitis (AgP) is a severe type of periodontal disease (PD) that affects younger patients (< 30 years), with the highest prevalence in populations of African descent. Features include bone loss around teeth, familial aggregation, and altered neutrophil function. Unraveling the genetic architecture of AgP may help us understand the molecular mechanisms underlying AgP and chronic PD, and could identify youth and young adults at risk for AgP.

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