Tobacco and alcohol use and persistent oral infection with human papillomavirus (HPV) are risk factors for oral cancer (OC) and oropharyngeal cancer (OPC). CDC estimates that approximately 60% of OPC cases in the United States are caused by HPV types 16/18. Previous studies (GWAS) suggest genetic factors are associated with an increased risk of developing HPV-related OPCs. Assessing genetic factors in a large population could help to explain variances in susceptibility to OC and OPC.
Idea No. 13