AoU Research Priorities Use Cases

What genetic factors are associated with oral cancer (OC) and oropharyngeal cancer (OPC)?

Tobacco and alcohol use and persistent oral infection with human papillomavirus (HPV) are risk factors for oral cancer (OC) and oropharyngeal cancer (OPC). CDC estimates that approximately 60% of OPC cases in the United States are caused by HPV types 16/18. Previous studies (GWAS) suggest genetic factors are associated with an increased risk of developing HPV-related OPCs. Assessing genetic factors in a large population could help to explain variances in susceptibility to OC and OPC.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Electronic Health Records (EHR)

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Once per year

Data Item #2

Method #2 Survey

Specification #2 Once per year

If Data Item #3 was not in the dropdown, please enter it here Lifestyle history

Method #3 Survey

Specification #3 Once per year

Data Item #4

Method #4 Survey

Specification #4 Once per year

Data Item #5 Genome

Method #5 Whole Genome Sequencing (WGS)

Specification #5 Once

If you have more than five data items, you may enter them here.

HPV sero-reactivity

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Idea No. 13