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What genetic markers can lead to early diagnosis of late-onset rare diseases (Huntington, Crohn, CMT, ALS, etc.)?

Most rare diseases, defined as those affecting fewer than 200,000 people, are genetic disorders with signs observable at birth or in childhood. However, a number have adult-onsets, such as Crohn, Charcot-Marie-Tooth, ALS or thyroid cancer. Of this subset, many have not been linked to a single genetic mutation or origin and similarly, do not have a usable biomarker for early diagnosis. Are there any genetic markers that can act as risk factors for development of these particular rare diseases?



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