AoU Research Priorities Use Cases

What genetic markers predict consequences of pregnancy associated hypertension & gestational diabetes for mothers & offspring?

This study will focus on women who are pregnant at enrollment or become pregnant during the study and the offspring of observed pregnancies. The information will help to define genetic and epigenetic predictors of long-term effects of common pregnancy complications.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. Genome

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Whole Genome Sequencing (WGS)

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Once

Data Item #2 History, obstetric

Method #2 Electronic Health Records (EHR)

Specification #2 Once per year

If Data Item #3 was not in the dropdown, please enter it here Blood pressure and Oral Glucose Tolerance Test results

If Method #3 was not in the dropdown, please enter it here Physical exam and Oral Glucose Tolerance Test

If Specification #3 was not in the dropdown, please enter it here At each prenatal visit

If Data Item #4 was not in the dropdown, please enter it here Height, weight, blood pressure, and diagnoses history

If Method #4 was not in the dropdown, please enter it here Physical exam and Electronic Health Records (EHR)

If Specification #4 was not in the dropdown, please enter it here Follow-up of offspring once annually for 10 years

If Data Item #5 was not in the dropdown, please enter it here Diagnoses of cardiovascular disease and events and type 2 diabetes

Method #5 Electronic Health Records (EHR)

If Specification #5 was not in the dropdown, please enter it here Follow-up of mothers once annually for 10 years

If you have more than five data items, you may enter them here.

Genetic and epigenetic markers from mothers and offspring

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Idea No. 77