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What happens to people before and as they come down with a disease? How do high-risk people who don't get the disease differ?

We can identify people who are at high risk for many diseases. However, not all high-risk people develop the disease. This study would follow people in high-risk groups longitudinally and identify specific genomic, physiological, clinical, and exposure factors that are either predictive or protective of transition to disease. This should focus on a diverse set of people (ethnicity, gender/sex, age, SES, rural/urban, geographic location, etc.) and measure many factors.

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Idea No. 809