AoU Research Priorities Use Cases

What is the population genetics of genes that code for drug-metabolizing enzymes? Do any correlate with drug reactions?

1) Collect the genetics of drug metabolizing enzymes from the genetic samples in the All Of Us study.

2) Describe the population genetics of these specific genes. How many people are normal (extensive metabolizers, EMs)? How many have other profiles? How many genes is the "average person" abnormal for?

3) By collecting data for "allergies" (some of which are intolerances, not true allergies) and medication reactions requiring medical care, can we show that non-EMs are at higher risk?

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Idea No. 42