AoU Research Priorities Use Cases

What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive models that could inform a “personalized microbiome growth curve."

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. History, health

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Electronic Health Records (EHR)

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Once per year

Data Item #2 History, medication

Method #2 Electronic Health Records (EHR)

Specification #2 Once per year

If Data Item #3 was not in the dropdown, please enter it here Microbiologic evaluation of oral, skin, and vaginal specimens

If Method #3 was not in the dropdown, please enter it here Physical Exam; oral, skin and vaginal specimen collection, microbiologic genome sequencing

Specification #3 Once per year

Data Item #4 Genome

Method #4 Whole Genome Sequencing (WGS)

Specification #4 Once per year

If Data Item #5 was not in the dropdown, please enter it here Immune and inflammatory biomarkers

Method #5 Blood test

Specification #5 Once per year

If you have more than five data items, you may enter them here.

-Participant provided information spanning the following fields: sociodemographic, environmental context, lifestyle survey, and diet survey.
-Clinical diagnostic tests for asthma, diabetes mellitus, and allergies.
-Pregnancy outcome and medical conditions related to pregnancy
-Mode of delivery history
-Breastfeeding history

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Idea No. 86