AoU Research Priorities Use Cases

What risk factors predispose children to sepsis, and what interventions are most effective for prevention and treatment?

This study will focus on the entire cohort of children (infants-18 y/o) and will identify those risk factors which predispose children to sepsis. The information will be used to create more precise strategies to identify individuals at highest risk of sepsis and to implement preventive or early treatment therapies that would improve outcomes. The study will also assess the use of adjunctive immunomodulatory therapies to inform their use with enhanced precision.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. Identification of sepsis

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Electronic Health Records (EHR)

If you did not find your methodology specifications for Data Item #1 above, please enter it here. Once. Identified septic participants will then be monitored for one year after the septic event

If Data Item #2 was not in the dropdown, please enter it here. Neurodevelopmental status

Method #2 Clinical diagnostic tests

If Specification #2 was not in the dropdown, please enter it here: One year after septic event

Data Item #3 Genome

Method #3 Whole Genome Sequencing (WGS)

Specification #3 Once

If Data Item #4 was not in the dropdown, please enter it here History of infections

Method #4 Electronic Health Records (EHR)

Specification #4 Once per year

Data Item #5 Physical activity level

Method #5 Mobile monitor

If Specification #5 was not in the dropdown, please enter it here Continuous for one year after the septic event; in children three and older

If you have more than five data items, you may enter them here.

-Participant Provided Information: Age (gestational age); gender; ethnicity; socioeconomic status; parental educational level
-Electronic Health Record provided information: hospitalizations history; co-morbid conditions; medication history (emphasis on antimicrobials, steroids, IVIG, Gm-CSF, and biologics); mental health history; disease diagnoses history; alcohol/drugs use history; immunization status; and source of sepsis (potential use of natural language processing for notes related to this variable)
-Physical Examination: BMI; height or weight/length
-Geocoding information
-Environmental exposure survey
-Third party payer information

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Idea No. 84