AoU Research Priorities Use Cases

Why are some people with multiple cardiovascular risk factors resilient against developing cardiovascular diseases?

People who smoke or have hypertension, diabetes, and hyperlipidemia are at increased risk of developing cardiovascular diseases (CVD). However, not all do, and it would be interesting to identify those with CVD risk factors but remain free of CVD. Studying these people phenotypically, genomically, environmentally, and molecularly (via -omics) could provide great insight into novel mechanisms by which new treatments may be developed and tested in future trials.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. Clinical outcomes

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Electronic Health Records (EHR)

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Once per year

Data Item #2 Genome

Data Item #3 Metabolic risk profile

Method #3 Blood test

If Data Item #4 was not in the dropdown, please enter it here omics

Data Item #5 Physical activity level

If you have more than five data items, you may enter them here.

Other data would be helpful as well, including social determinants of health, behavioral beyond physical activity and diet, and environmental exposures...

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Idea No. 450