AoU Research Priorities Use Cases

Why do individuals with autoimmune diseases have an increased risk of lymphoma and how can we prevent it?

Studies have shown that individuals with autoimmune diseases and other immune disorders are at increased the risk of developing lymphoma later in life, but the biological mechanisms are unclear. Better characterization of the risk, specific lymphoma subtypes involved, and the impact of treatment along with an understanding of disease mechanisms is critical for prevention of lymphoma in this highly susceptible population.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

Select your required Data Item #1, which is most important to your study. This would be an item that needs to be generated and collected from different sources using various procedures, tools, techniques, assays, etc. If not in the current selection, please enter it in the textbox below. Cancer incidence

By what method will Data Item #1 be obtained? This may Include procedures, tools, techniques, assays, and analytical approaches for the collection, measurement, or analysis of data. If you do not find the required method, you may enter it in the textbox below. Electronic Health Records (EHR)

If you did not find your method for obtaining Data Item #1 in the dropdown selection above, please enter it here. linkage to cancer registries may be necessary for complete ascertainment

Are there specifications that apply to the method by which Data Item #1 will be obtained, e.g., is the measurement taken once a year, every month, or some other variation? If you do not find your specification in the dropdown, you may enter it in the textbox below. Once per year

If Data Item #2 was not in the dropdown, please enter it here. History and incidence of autoimmune disease and other immune disorders

Method #2 Electronic Health Records (EHR)

If Method #2 was not in the dropdown, please enter it here Survey may be necessary to capture history of autoimmune diseases

Specification #2 Once per year

If Data Item #3 was not in the dropdown, please enter it here Lymphoma morphology and subtype classification information

If Method #3 was not in the dropdown, please enter it here Pathology reports including detailed subtype information critical for classification of specific lymphoid malignancy

Specification #3 Once per year

If Data Item #4 was not in the dropdown, please enter it here Treatment for autoimmune/immune-related disorders; Immune-related medications

Method #4 Electronic Health Records (EHR)

Specification #4 Once per year

Data Item #5 Genome

Method #5 Whole Genome Genotyping (WGG)

Specification #5 Once

If you have more than five data items, you may enter them here.

HLA genotyping; tumor blocks

Voting

2 votes
Ideate
Idea No. 771