AoU Research Priorities Use Cases

Why do some previosuly healthy infants and toddlers develop severe lower respiratory tract infections with common viruses?

This would be designed as a prospective observational cohort study of children (infants to 2 year olds) with common seasonal respiratory viral illnesses (RSV, enterovirus/rhinovirus, human metapneumovirus, parainfluenza, influenza). Those with severe bronchiolitis/pneumonia requiring hospitalizations would then be compared to those who receive care as outpatients. The analysis would include clustering based on genetic variants, microbiome composition, and phenotypic characteristics.



4 votes
Idea No. 543