AoU Research Priorities Use Cases

Would the addition of non-selective beta-blockers to cancer therapy result in better survival?

Animal models are compelling that activating the beta-adrenergic pathway (via stress) results in tumor growth and metastasis. Beta-blockers blunt this effect in animals. All of Us could design a randomized intervention trial to test this potential benefit in humans. An observational approach could also be taken with careful attention to pharmacoepi principles and biases such as confounding by indication.

The remaining questions allow you to outline in more detail the information needed to address your research question. The series of questions allow up to five entries. If you have more than five entries, please try to prioritize them and enter the remainder in the final field. When done, click Submit at the bottom. No

If you did not find your Data Item #1 in the dropdown selection above, please enter it here. cancer diagnosis

If Data Item #2 was not in the dropdown, please enter it here. cancer treatment details

If Data Item #3 was not in the dropdown, please enter it here beta blocker use (assigned or from survey depending on trial or observational)

If Data Item #4 was not in the dropdown, please enter it here all comorbidities

If Data Item #5 was not in the dropdown, please enter it here behavioral and demographic confounders

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Idea No. 746