Showing 2 ideas for tag "age-related-macular-degeneration"
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Can we identify risk factors for Age Related Macular Degeneration (AMD) ?

From NEI Working Group on AMD
Use cohort with structural and functional phenotyping with genetic and EHRs to identify risk factors, and their interactive effects, for AMD development/progression. A subset could be identified based on AMD or family history of AMD (via EHRs), or presence of high-risk variants (via WGS), and could then be followed annually with fundus autofluorescence, OCT, dark adaptation. Additional... more »

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AoU Research Priorities Use Cases

Gene*Environment Interactions and Chronic Eye Disease outcomes

Leverage sample size to investigate genetic polymorphism and environment exposure (G*E) interactions in chronic eye disease. Smaller studies are suggestive, yet few adequately powered studies exist. As chronic eye disease shares cardiovascular disease (CVD) risk factors, focusing on CVD G*E interactions may identify novel risk factors and targets to reduce eye disease risk/burden. Potential examples include MTHFR polymorphisms... more »

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