Clinical evidence suggests that cancer survivors, people living with HIV/AIDS, and diabetics may age prematurely from treatment toxicity. The All of Us study could be used to study these observatons over time by comparing aging trajectories and risk factors for individuals with and without systemic therapy use and investigate the mechanisms that cause alterations in the rate or way individuals age.
Medicare penalizes hospitals that must readmit patients within 30 days. To what extent are those treatment failures linked to a failure to personalize medications and dosages? Metabolism and weight changes make the elderly more sensitive to dose variation. CYP phenotyping could be requested or incentivized as part of the readmission.
Survey those individuals as to their life experiences - medical history, employment history, lifestyle, exercise history, diet etc
Individuals will provide a blood sample for complete genetic analysis.
What genetic mutations are present which may cause cancer yet... more »
Use cohort with structural and functional phenotyping with genetic and EHRs to identify risk factors, and their interactive effects, for AMD development/progression. A subset could be identified based on AMD or family history of AMD (via EHRs), or presence of high-risk variants (via WGS), and could then be followed annually with fundus autofluorescence, OCT, dark adaptation. Additional... more »