Showing 20 ideas for tag "biomarkers"
(@drirene) kudos icon +

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Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health.
Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary... more »

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219 votes
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(@renaissance) kudos icon +

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How reliably do epigenetic aging clocks predict disease onset and mortality? Can they be slowed or reversed?

An annual blood test with analysis of methylation sites from key epigenetic aging clocks (e.g. Horvath). Epigenetic aging clocks have already been shown to reliably predict age, time-to-death, all cause mortality, cog. function, immune function, CV disease, cancer, and more. They may also become a key tool to demonstrate the reversibility of disease risk through dietary and therapeutic regimens, as epigenetic states are... more »

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35 votes
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(@sjogrens.syndrome.foundation) kudos icon +

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Biomarker identification to help improve diagnosis, identify risk factors, and better classify patients with autoimmune diseases

For many autoimmune diseases, such as Sj√∂gren's, a lack of clinical, hematological and histological biomarkers has proven to be a hindrance to our understanding, management, and treatment of the disease. This study would focus on identifying such biomarkers in patients with autoimmune diseases to help improve diagnosis, better classify patients, and identify risk factors, and have the potential to show improvement with... more »

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32 votes
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(@pgejman) kudos icon +

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Do blood biomarkers predict mood transitions for peripartum mood disorder (PPMD)?

Mood disorder in pregnant and postpartum women is common, often severe, but frequently undiagnosed and untreated, and largely understudied. I propose to augment the AllofUs protocol for research into PPMD by adding collection of biospecimens for OMIC measurements at fixed times relative to pregnancy, and also when triggered by alerts of critical clinical mood state shifts as informed by wearable technology or computerized... more »

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14 votes
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(@drirene) kudos icon +

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How can "All of Us" researchers collaborate to address differences and unique patterns of every individual?

Each of Us is Unique, All of Us should work together. Some diseases are generously funded because advocacy groups have powerful lobbying arms. Every individual affected could potentially contribute valuable data to different medical subspecialities. We should not box people in ICD codes, but use a narrative-based approach, stop dismissing patients' observations and patterns of limited significance - as it could lead to... more »

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17 votes
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(@pjb000) kudos icon +

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Will the clinical use of predictive glycation and oxidation biomarkers improve diabetes care and prevent long-term complications

Since diabetic complications occur in those that show more glycative and oxidative stress, we have validated their predictive power in ground-breaking outcome trials to create diagnostic blood tests for clinical use.
To study the clinical efficacy and utility of these tests we will identify those at high risk (HR) before DKD and CVD are apparent. Primary endpoints are achievement of rigorous glycemic and proposed treatment... more »

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11 votes
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(@changhu) kudos icon +

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What are the genetic, comorbid risk factors, and anticancer agents that contribute to heart failure after cancer therapy

Goals:To study the epidemiology of cardiovascular complications of cancer therapy in order to design prevention strategy and precision treatment of cancer patients while minimizing debilitating cardiovascular complications. Methods: compare data on genetic, co morbid risk factors, and anticancer agents used in association with cardiovascular complications after cancer therapy. Expected outcomes: This study will provide... more »

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11 votes
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(@maria.spletter) kudos icon +

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Does data from deep sequencing tumors (personalized medicine) allow for targeted treatment and better survival of patients?

1. Divide "cancer" into multiple classes (ie breast, lung, pancreatic, etc.) and sequence tumors from 50-100 patients undergoing treatment. As with breast cancer, identify markers aligning with specific treatments and outcomes.
2. Perform the "clinical" trial. Use the deep sequencing as a diagnostic to aid in planning the treatment for a set of 50-100 patients for a given type of cancer. Track the outcomes: survival time,... more »

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5 votes
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(@mnulam) kudos icon +

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What are the mechanisms underlying fatigue?

Fatigue is a ubiquitous symptom commonly reported in people with acute and chronic illness. We do not know the specific underlying mechanisms of fatigue; some studies suggest inflammation, the hypothalamic pituitary adrenal (HPA) axis and the autonomic nervous system are implicated in fatigue. We propose longitudinal assessments of self-reported fatigue and inflammatory biomarkers monthly over 1 year to determine those... more »

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7 votes
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(@petercastellano6) kudos icon +

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How Do We Define Health and Then How do we measure it?

What does health mean these days? Health has 2 components: (1) mental and emotional happiness, which is harder to measure, and (2) biochemical health, which is measureable.
Goals: Define Health and then Define measurements (markers) of Health
Methods: Set forth the measurements of health, monitor and collect the dietary and biomarker data of people overtime, and record good/bad outcomes and then related back to dietary... more »

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3 votes
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(@brodyj) kudos icon +

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What are the best ways to report back to participants on biomarkers for environmental chemicals?

All of Us has committed to reporting back to participants on their biomarkers. The study can advance methods for reporting on environmental chemicals in the context of genetic data and health by studying the experiences of All of Us participants, including how they view and use their reports, their cognitive and emotional responses, and other outcomes.

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5 votes
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(@visarb) kudos icon +

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Can measures of speech and language be pre-clinical predictors of neurological disease?

Complex brain networks are responsible for translating thoughts and ideas into sequences of movements that produce the sounds of speech. Any disturbance in these networks can lead to changes in how we speak and what we say. Evidence shows that subtle changes in speech are early harbingers of neurological disease. We propose to use the AoU platform to validate this hypothesis on a large scale and to develop AI tools for... more »

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2 votes
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