EDCs are widespread in consumer products, air, and drinking water. Cancer treatments (such as tamoxifen and aromatase inhibitors for breast cancers) depend on altering the body's hormone levels. All of Us could evaluate whether EDCs interfere with cancer treatments. This study would involve assessing EDC exposure in patients during treatment and evaluating hormonal outcomes and disease progression outcomes.

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine biomarkers that could help push this field of research forward in a valid way for the future. Such biomarkers could be a part of individual studies of stress and disease, and could also be used as a gold standard to develop... more »

Osteoarthritis (OA) is the most common cause of disability in the United States, and there are no available biomarkers or disease-modifying therapies for OA. Currently, we are unable to identify rapidly progressive OA patients at diagnosis. All of Us offers a unique opportunity to obtain clinical data and biospecimens, along with diet and exercise information, which associate with rapidly progressive OA to help foster... more »

Autoimmune diseases afflict nearly 1 in 12 Americans and many more have autoantibodies but no evidence of clinical disease. Recent work has identified biomarkers or clinical symptoms which associate with subsequent developing development of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) and NIH-funded prevention trials are underway. AoU provides a unique opportunity to identify at risk individuals through... more »

Half of all Americans are diagnosed with one or more chronic illnesses, like heart disease and cancer. Mindsets about these illnesses may have a profound impact on the diagnosis, progression, and treatment of these illnesses. This study aims to: (1) understand the distribution of mindsets held by a diverse group of both healthy and chronically ill Americans, and (2) identify relationships between these mindsets, biomarkers... more »