Half of all Americans are diagnosed with one or more chronic illnesses, like heart disease and cancer. Mindsets about these illnesses may have a profound impact on the diagnosis, progression, and treatment of these illnesses. This study aims to: (1) understand the distribution of mindsets held by a diverse group of both healthy and chronically ill Americans, and (2) identify relationships between these mindsets, biomarkers... more »

Osteoarthritis (OA) is the most common cause of disability in the United States, and there are no available biomarkers or disease-modifying therapies for OA. Currently, we are unable to identify rapidly progressive OA patients at diagnosis. All of Us offers a unique opportunity to obtain clinical data and biospecimens, along with diet and exercise information, which associate with rapidly progressive OA to help foster... more »

Autoimmune diseases afflict nearly 1 in 12 Americans and many more have autoantibodies but no evidence of clinical disease. Recent work has identified biomarkers or clinical symptoms which associate with subsequent developing development of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) and NIH-funded prevention trials are underway. AoU provides a unique opportunity to identify at risk individuals through... more »

Complex brain networks are responsible for translating thoughts and ideas into sequences of movements that produce the sounds of speech. Any disturbance in these networks can lead to changes in how we speak and what we say. Evidence shows that subtle changes in speech are early harbingers of neurological disease. We propose to use the AoU platform to validate this hypothesis on a large scale and to develop AI tools for... more »

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EDCs are widespread in consumer products, air, and drinking water. Cancer treatments (such as tamoxifen and aromatase inhibitors for breast cancers) depend on altering the body's hormone levels. All of Us could evaluate whether EDCs interfere with cancer treatments. This study would involve assessing EDC exposure in patients during treatment and evaluating hormonal outcomes and disease progression outcomes.

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine biomarkers that could help push this field of research forward in a valid way for the future. Such biomarkers could be a part of individual studies of stress and disease, and could also be used as a gold standard to develop... more »

What does health mean these days? Health has 2 components: (1) mental and emotional happiness, which is harder to measure, and (2) biochemical health, which is measureable.
Goals: Define Health and then Define measurements (markers) of Health
Methods: Set forth the measurements of health, monitor and collect the dietary and biomarker data of people overtime, and record good/bad outcomes and then related back to dietary... more »

All of Us has committed to reporting back to participants on their biomarkers. The study can advance methods for reporting on environmental chemicals in the context of genetic data and health by studying the experiences of All of Us participants, including how they view and use their reports, their cognitive and emotional responses, and other outcomes.

Fatigue is a ubiquitous symptom commonly reported in people with acute and chronic illness. We do not know the specific underlying mechanisms of fatigue; some studies suggest inflammation, the hypothalamic pituitary adrenal (HPA) axis and the autonomic nervous system are implicated in fatigue. We propose longitudinal assessments of self-reported fatigue and inflammatory biomarkers monthly over 1 year to determine those... more »

1. Divide "cancer" into multiple classes (ie breast, lung, pancreatic, etc.) and sequence tumors from 50-100 patients undergoing treatment. As with breast cancer, identify markers aligning with specific treatments and outcomes.
2. Perform the "clinical" trial. Use the deep sequencing as a diagnostic to aid in planning the treatment for a set of 50-100 patients for a given type of cancer. Track the outcomes: survival time,... more »

Goals:To study the epidemiology of cardiovascular complications of cancer therapy in order to design prevention strategy and precision treatment of cancer patients while minimizing debilitating cardiovascular complications. Methods: compare data on genetic, co morbid risk factors, and anticancer agents used in association with cardiovascular complications after cancer therapy. Expected outcomes: This study will provide... more »

Since diabetic complications occur in those that show more glycative and oxidative stress, we have validated their predictive power in ground-breaking outcome trials to create diagnostic blood tests for clinical use.
To study the clinical efficacy and utility of these tests we will identify those at high risk (HR) before DKD and CVD are apparent. Primary endpoints are achievement of rigorous glycemic and proposed treatment... more »

Mood disorder in pregnant and postpartum women is common, often severe, but frequently undiagnosed and untreated, and largely understudied. I propose to augment the AllofUs protocol for research into PPMD by adding collection of biospecimens for OMIC measurements at fixed times relative to pregnancy, and also when triggered by alerts of critical clinical mood state shifts as informed by wearable technology or computerized... more »

Each of Us is Unique, All of Us should work together. Some diseases are generously funded because advocacy groups have powerful lobbying arms. Every individual affected could potentially contribute valuable data to different medical subspecialities. We should not box people in ICD codes, but use a narrative-based approach, stop dismissing patients' observations and patterns of limited significance - as it could lead to... more »