EDCs are widespread in consumer products, air, and drinking water. Cancer treatments (such as tamoxifen and aromatase inhibitors for breast cancers) depend on altering the body's hormone levels. All of Us could evaluate whether EDCs interfere with cancer treatments. This study would involve assessing EDC exposure in patients during treatment and evaluating hormonal outcomes and disease progression outcomes.
Goals: Define Health and then Define measurements (markers) of Health
Methods: Set forth the measurements of health, monitor and collect the dietary and biomarker data of people overtime, and record good/bad outcomes and then related back to dietary... more »
All of Us has committed to reporting back to participants on their biomarkers. The study can advance methods for reporting on environmental chemicals in the context of genetic data and health by studying the experiences of All of Us participants, including how they view and use their reports, their cognitive and emotional responses, and other outcomes.
2. Perform the "clinical" trial. Use the deep sequencing as a diagnostic to aid in planning the treatment for a set of 50-100 patients for a given type of cancer. Track the outcomes: survival time,... more »
To study the clinical efficacy and utility of these tests we will identify those at high risk (HR) before DKD and CVD are apparent. Primary endpoints are achievement of rigorous glycemic and proposed treatment... more »