Showing 21 ideas for tag "cardiovascular"
(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Common blood pressure (BP) trajectories across the lifespan and their impact on cardiovascular diseases

Following AoU participants for decades could uncover common trajectories of BP across lifespan and their associations/impact on cardiovascular diseases (CVD). AoU’s size/diversity also enables precise measure of the associations by different subgroups (e.g., race, sex, social factors, presence of multiple risk factors). This could lead to refined risk predictions for CVD and further shed light on optimal timing for initiating... more »

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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Toward a more precise risk prediction for ischemic stroke in Asians Americans with Atrial Fibrillation (AF)

Research in Asia vs. findings in U.S. suggest risk of ischemic stroke AND bleeding with oral anticoagulant may be higher in East Asian vs. non-Asian AF patients. However, data is lacking in Asians living in the U.S. With its diversity goal, AoU is expected to recruit substantive number of Asian Americans. AoU can be leveraged to see whether this finding extends to Asian Americans, who have different exposures (behavioral,... more »

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(@jenna.norton) kudos icon +

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Can inclusion of erectile dysfunction (ED) improve prediction of incident cardiovascular disease (CVD)?

Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.

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(@dawn.harris99) kudos icon +

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Do patients have better outcomes post- routine heart catheterization than those who elect to not have the procedure?

Every year over one million heart catheterizations are performed in the United States alone. This study would aim to find if these procedures truly benefit the patient or if they are unnecessarily performed. In order to get accurate results the study would need to take place over a 3-5 year time frame comparing those who had the procedure and those who elected to forgo. The study would monitor the subjects' cardiac-related... more »

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4 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

In elderly with stable obstructive coronary disease, what factors predict long-term stability w/ medical management alone?

The number of elderly with heart disease is growing. AoU can address key questions by following the clinical management and outcome of these patients – e.g., among elderly patients with recently diagnosed chronic stable obstructive coronary disease, what factors (comorbidity, genomics, socio/environmental, behavioral) predict long-term stability with medical management alone vs. coronary revascularizations? And how does... more »

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3 votes
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(@wye000) kudos icon +

AoU Research Priorities Use Cases

What is the long-term comparative effectiveness of empagliflozin in a heterogeneous population with type 2 diabetes?

Empaglifozin, a highly selective sodium-glucose cotransport 2 (SGLT2) inhibitor, has been shown to significantly reduce major adverse cardiovascular (CV) events and hospitalization for heart failure in patients with type 2 diabetes (T2DM) and established CV disease. The generalizability of this finding to lower risk population is unknown. We propose to compare cardiovascular outcomes in a more heterogeneous population... more »

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