Showing 21 ideas for tag "cardiovascular"
(@wye000) kudos icon +

AoU Research Priorities Use Cases

What is the long-term comparative effectiveness of empagliflozin in a heterogeneous population with type 2 diabetes?

Empaglifozin, a highly selective sodium-glucose cotransport 2 (SGLT2) inhibitor, has been shown to significantly reduce major adverse cardiovascular (CV) events and hospitalization for heart failure in patients with type 2 diabetes (T2DM) and established CV disease. The generalizability of this finding to lower risk population is unknown. We propose to compare cardiovascular outcomes in a more heterogeneous population... more »

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3 votes
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(@dawn.harris99) kudos icon +

AoU Research Priorities Use Cases

Do patients have better outcomes post- routine heart catheterization than those who elect to not have the procedure?

Every year over one million heart catheterizations are performed in the United States alone. This study would aim to find if these procedures truly benefit the patient or if they are unnecessarily performed. In order to get accurate results the study would need to take place over a 3-5 year time frame comparing those who had the procedure and those who elected to forgo. The study would monitor the subjects' cardiac-related... more »

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4 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

In elderly with stable obstructive coronary disease, what factors predict long-term stability w/ medical management alone?

The number of elderly with heart disease is growing. AoU can address key questions by following the clinical management and outcome of these patients – e.g., among elderly patients with recently diagnosed chronic stable obstructive coronary disease, what factors (comorbidity, genomics, socio/environmental, behavioral) predict long-term stability with medical management alone vs. coronary revascularizations? And how does... more »

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3 votes
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(@ginawei) kudos icon +

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Toward a more precise risk prediction for ischemic stroke in Asians Americans with Atrial Fibrillation (AF)

Research in Asia vs. findings in U.S. suggest risk of ischemic stroke AND bleeding with oral anticoagulant may be higher in East Asian vs. non-Asian AF patients. However, data is lacking in Asians living in the U.S. With its diversity goal, AoU is expected to recruit substantive number of Asian Americans. AoU can be leveraged to see whether this finding extends to Asian Americans, who have different exposures (behavioral,... more »

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6 votes
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(@jenna.norton) kudos icon +

AoU Research Priorities Use Cases

Can inclusion of erectile dysfunction (ED) improve prediction of incident cardiovascular disease (CVD)?

Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.

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7 votes
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(@ginawei) kudos icon +

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Importance of identifying & recruiting Asian American subgoups in All of Us

Most data from U.S. registries, EHR, death cert., & cohort studies do not differentiate among Asian American subgroups (6 largest: Chinese, S. Asian, Filipino, Vietnamese, Korean & Japanese). Limited data to date suggests evidence of subgroup heterogeneity, including differences in prevalence of cardiovascular risk factors and diseases, which would be masked if subgroups are aggregated. AoU deserves kudos for collecting... more »

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9 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

How well do the ACC/AHA Atherosclerotic Cardiovascular Disease (ASCVD) risk scores work in Asian Americans?

The ASCVD risk scores was introduced by American College of Cardiology (ACC) & American Heart Association (AHA) in 2013 to provide 10-year risk for use in Blood Cholesterol Guideline. Absence of Asian Americans in the cohorts that provided the data for developing the scores may limit its precision in these individuals. AoU offers unique opportunity to collect CVD risk factors & outcomes in Asian Americans and its heterogeneous... more »

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9 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Identify and create a cohort of heart failure patients within All of Us to enable discovery and clinical research

Prevalence of heart failure (HF) in U.S. has risen to ~6.1 million among those ≥20 years of age. AoU provides a rich platform to identify HF patients through EHR (including clinical laboratory and imaging reports) and claims data. Ability to follow and collect data prospectively in the patients, including ancillary studies of more surveys and imaging/biomarker collections, could advance discovery science and address... more »

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9 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Common blood pressure (BP) trajectories across the lifespan and their impact on cardiovascular diseases

Following AoU participants for decades could uncover common trajectories of BP across lifespan and their associations/impact on cardiovascular diseases (CVD). AoU’s size/diversity also enables precise measure of the associations by different subgroups (e.g., race, sex, social factors, presence of multiple risk factors). This could lead to refined risk predictions for CVD and further shed light on optimal timing for initiating... more »

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7 votes
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(@jconstible) kudos icon +

AoU Research Priorities Use Cases

Do residential energy efficiency measures improve physical and mental health?

Goal: Identify and quantify health benefits of energy efficiency measures in single- or multi-family housing.

Data tools: Resident surveys, air pollution monitors, temperature monitors, energy usage data from electric utilities.

Expected outcomes: Previous qualitative and quantitative work suggests residents of more energy efficient homes experience fewer cardiovascular symptoms (e.g., asthma attacks) and fewer exposures... more »

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9 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Develop more accurate and clinically relevant sub-classification/phenotyping of heart failure

Heart failure (HF), though relatively common in U.S. adults, can be thought of as a syndrome with many subtypes that require different treatments. All of Us provides a rich platform on which to collect more data (e.g., novel biomarkers and imaging studies) on HF patients. This, coupled with AoU’s existing rich genomics, behavioral, and clinical data, can be analyzed to refine the phenotyping and sub-classification of... more »

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9 votes
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(@ginawei) kudos icon +

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Why are some people with multiple cardiovascular risk factors resilient against developing cardiovascular diseases?

People who smoke or have hypertension, diabetes, and hyperlipidemia are at increased risk of developing cardiovascular diseases (CVD). However, not all do, and it would be interesting to identify those with CVD risk factors but remain free of CVD. Studying these people phenotypically, genomically, environmentally, and molecularly (via -omics) could provide great insight into novel mechanisms by which new treatments... more »

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13 votes
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(@pnatarajan) kudos icon +

AoU Research Priorities Use Cases

How do environmental exposures, behavior, & genetics, in combination, influence risk of atherosclerotic cardiovascular disease.

Genetics can be the earlier risk predictor of common, heritable traits such as atherosclerotic cardiovascular disease (ASCVD). Longitudinal environmental exposures and behavioral practices subsequently modify risk. Uniform dense ascertainment of environmental exposures and behavior is feasible through wearable sensors. We and others are beginning to look at the comprehensive set of exposures that influence ASCVD risk.... more »

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12 votes
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(@ruthi10032) kudos icon +

AoU Research Priorities Use Cases

Bridging the gap between obstetric history (preeclampsia) and future women's health and cardiovascular outcomes

2 possible designs:
1) Enroll women diagnosed with preeclampsia (PEC) during current pregnancy and collect data (phenotype & biomarkers), follow up prospectively until cardiovascular events (acute coronary events, strokes, including cardiac surgery)
2) Ambidirectional design: enroll women with a PEC history now having cardiac surgery/cardiopulmonary bypass (CPB); collect biomarkers & clinical outcomes (phenotype after... more »

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11 votes
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(@ndgidea) kudos icon +

AoU Research Priorities Use Cases

How can cardio- and cerebrovascular health education and treatment be leveraged to improve brain health throughout life?

Cardio- and cerebrovascular disease are linked to poor brain health outcomes, including dementia. To increase public health impact of this knowledge, better train care providers to identify and counter vascular risk and disease (e.g. hypertension, clots, diabetes, metabolic syndrome) in everyday care settings, and better educate patients on the importance of vascular health and related lifestyle decisions for brain health.... more »

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11 votes
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